Simultaneous detection of BRCA mutations and large genomic rearrangements in germline DNA and FFPE tumor samples
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چکیده
منابع مشابه
Simultaneous detection of BRCA mutations and large genomic rearrangements in germline DNA and FFPE tumor samples
The development of breast and ovarian cancer is strongly connected to the inactivation of the BRCA1 and BRCA2 genes by different germline and somatic alterations, and their diagnosis has great significance in targeted tumor therapy, since recently approved PARP inhibitors show high efficiency in the treatment of BRCA-deficient tumors. This raises the need for new diagnostic methods that are cap...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2016
ISSN: 1949-2553
DOI: 10.18632/oncotarget.11259